Talk:Zanamivir

History
The history cited in this article conflicts with other histories available online, such as that at the CSIRO website (http://www.csiro.au/solutions/Relenza.html). For example it incorrectly cites Colman and Laver as the discoverers of Zanamivir, when in fact they identified the static neuraminidase protein that occurs in all strains of influenza. Von Itzstein's team discovered the molecule, Zanamivir, that blocks that protein. Thus it's von Itzstein who is credited as the discoverer of Relenza. Also, Biota didn't fund the initial research into the discovery of the neuraminidase, only the discovery of Zanamivir.

Other histories might need to be checked to clarify this section. Tczuel (talk) 00:35, 11 August 2009 (UTC)


 * I've restored the material surrounding von Itzstein's role, which had been removed about a week ago. Emw2012 (talk) 16:41, 12 August 2009 (UTC)

Bird Flu
According to a new study, it might be of help against the feared H5N1:

"This research points to swift and effective use of antivirals, such as Tamiflu or Relenza, in order to prevent virus levels from rising too fast."

http://www.medicalnewstoday.com/healthnews.php?newsid=51587

-- MyrddinEmrys 23:56, 11 September 2006 (UTC)

Progression of Relenza
Paragraphs 3 and 4 of this section (the ones starting "Computational chemistry techniques to probe the active site of the enzyme" and "The strategy relied on the availability") are a mess. They contain random italics, some asterisks, and sentences that don't make sense. I'm pretty sure that some of this section may have been copied from a paper with "we" replaced by "they". Can someone who knows what they're talking about fix this please? Baratron (talk) 20:43, 29 March 2009 (UTC)

Relation to Swine Flu
I have seen articles that indicate this drug as being used to treat swine flu w/ success (along w/ Tamiflu). I was surprised to see no reference to it in the article. Todd (talk) 11:26, 28 April 2009 (UTC)

Proposing deletion of most of 'Development' section
In my opinion, the Development section contains a lot of background information that isn't immediately relevant to zanamivir. For example, it doesn't seem necessary to go into detail about the background of influenza (as the first paragraph of the Background section does -- the same goes for influenza A or B.  Unless some cogent arguments to keep these sections are forwarded within the next three days, I plan on removing the irrelevant details and merging the relevant content about zanamivir into other sections. Cheers, Emw2012 (talk) 20:12, 28 April 2009 (UTC)

Copyright problem removed
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Preservative
Forgive me if I've missed this information but what preservative is used in this vaccine? The NNii says that influenza vaccine is "manufactured with thimerosal as a preservative", does Zanamivir contain thimerosal? Thanks. Mimi (yack) 21:00, 9 August 2009 (UTC)
 * Zanamivir is a drug, not a vaccine. Neither zanamivir nor oseltamivir contain thimerosal. Fvasconcellos (t·c) 00:06, 10 August 2009 (UTC)


 * Many thanks. Mimi (yack) 09:15, 10 August 2009 (UTC)

Chemical synthesis
The Tamiflu entry (http://en.wikipedia.org/wiki/Tamiflu ) contains a very nice graphic showing the chemical synthesis. They further describe/discuss the problems in the production pipeline. It would be very interesting to have a similar entry for Relenza. Thanks. Jahibadkaret (talk) 11:24, 3 September 2009 (UTC)

Too Technical?
The second paragraph in "history" seems to be a bit technical for the average reader... anyone think we should maybe dum it down for the masses a bit.. -Tracer9999 (talk) 14:30, 13 October 2009 (UTC)

Something from 1918
I knew a girl who's name was ENZA I opened the window and In flu enza

--77.182.164.130 (talk) 11:31, 13 May 2013 (UTC)

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