The Last Man on Earth

(The) Last Man on Earth may refer to:


 * Last Man on Earth (1982 book), science fiction anthology edited by Isaac Asimov
 * Last Man on Earth (album), a 2001 album by Loudon Wainwright III
 * "The Last Man on Earth" (song), a 2021 song by Wolf Alice from their album Blue Weekend
 * The Last Man on Earth (1924 film), a silent comedy film
 * The Last Man on Earth (1964 film), an Italian science fiction film starring Vincent Price
 * The Last Man on Earth (2011 film), an Italian science fiction film by Gipi
 * The Last Man on Earth (TV series), a 2015 American comedy television series