The Perfect Drug

"The Perfect Drug" is a song by Nine Inch Nails written for the David Lynch film Lost Highway. It was released in 1997 on the Lost Highway soundtrack as well as a single from the score. Remixes of the song were released as an EP, "The Perfect Drug" Versions.

Though "The Perfect Drug" Versions acts as a single for the titular song, the original version does not appear on the EP. The track has also been included on international singles "We're in This Together, Part 3" and "Into the Void" without the ending truncated; the only audio release of it in North America being on the Lost Highway soundtrack. A music video for the song, directed by Mark Romanek, was included with the VHS compilation Closure and in The Work of Director Mark Romanek.

In September 2018 the band performed the song live for the first time at Red Rocks Amphitheatre.

Song
"The Perfect Drug" was described by Entertainment Weekly as a "drum-and-bass-infused industrial pop song". The Guardian also noted the drum and bass influence in the song. Despite being a single, "The Perfect Drug" did not appear live until September 18, 2018 at Red Rocks Amphitheatre in Colorado. On the official NIN website, a fan asked whether the track had not been performed live is because "the drum solo would make Jerome's arms fall off." Then-drummer Jerome Dillon replied that they "never rule out the possibility of playing any of the songs live."

On April 6, 2005, while presenting the late-night BBC Radio 1 Rock Show in the UK, Trent Reznor responded to the question, "Which piece of your own work are you least satisfied with and why?" by saying:

"'The only thing I think I really don't like that much is 'The Perfect Drug' song. It was one of those things where you have a week to do a track for a movie, the mindset that you kind of adapt in that situation, or I did, was 'let's go in and experiment and see what happens, and it's not, y'know, whatever comes out of it, it's not the end of the world'. And I think what came out of it, married with a bloated, over-budget video, feels like ... the least thing that I would play to somebody if they said play me, y'know, the top hundred songs you've written, that probably wouldn't be in the top hundred. I'm not cringing about it, but it's not my favorite piece.'"

Music video
A music video for the single was directed by Mark Romanek and released on January 18, 1997. The theme was inspired by the illustrations of 20th-century artist Edward Gorey, with familiar Gorey elements including oversized urns and glum, pale characters in full Edwardian costume. The most obvious reference to Gorey is the boy sitting on a cushion in front of a painting. Other references include an unidentified painting resembling Gustav Klimt's The Kiss (1907–1908) and a "Scanning Machine" designed by Frenchman François Willème in 1860.

Charlie Clouser, Danny Lohner, and Chris Vrenna also appear in the video, most notably playing string instruments at the beginning of the video. The first half of the video was filmed with a blue tint, switching to a flashing green light during the drum breakdown and reverting to blue for the remainder of the song. Joanne Gair's work with Nine Inch Nails on "The Perfect Drug" won her the makeup portion of the award for best hair/makeup in a music video at the Music Video Production Awards.

EP
"The Perfect Drug" Versions is the eleventh official Nine Inch Nails release and consists of five remixes of the song "The Perfect Drug." The European, Australian, and Japanese releases append the original version of the song, while a promotional vinyl set adds an exclusive sixth remix, by Aphrodite.

Track listing
Available as United States, Australia, Japan or EU single.

Cover versions and samples
In 2002, American post-hardcore band the Blood Brothers sampled the song in their song "Kiss of the Octopus". American deathcore band Fit for an Autopsy covered the song for the split EP The Depression Sessions in 2016.

In media
In January 2023, the song was licensed for the game Hi-Fi Rush and was featured in the final boss fight.