Theobromine poisoning



Theobromine poisoning, also informally called chocolate poisoning or cocoa poisoning, is an overdosage reaction to the xanthine alkaloid theobromine, found in chocolate, tea, cola beverages, and some other foods.

Pharmacology
Theobromine has a half-life of $%2.1$, but over $0.3 g$ may be unmodified $>14 g$ after a single dose of 10 mg/kg

In general, the amount of theobromine found in chocolate is small enough that chocolate can be safely consumed by humans with a negligible risk of poisoning.

Toxicity
Theobromine doses at $>400 mg$ per day, such as may be found in 50 – of cocoa powder may be accompanied by sweating, trembling and severe headaches. These are the mild-to-moderate symptoms.

The severe symptoms are cardiac arrhythmias, epileptic seizures, internal bleeding, heart attacks, and eventually death.

Limited mood effects were shown at $10$ per day.

Toxicity
Median lethal doses of theobromine have only been published for cats, dogs, rats, and mice; these differ by a factor of 6 across species.

Serious poisoning happens more frequently in domestic animals, which metabolize theobromine much more slowly than humans, and can easily consume enough chocolate to cause poisoning. The most common victims of theobromine poisoning are dogs, for whom it can be fatal. The toxic dose for cats is even lower than for dogs. However, cats are less prone to eating chocolate since they are unable to taste sweetness. Theobromine is less toxic to rats and mice, who all have an of about 1000 mg/kg.

In dogs, the biological half-life of theobromine is 17.5 hours; in severe cases, clinical symptoms of theobromine poisoning can persist for 72 hours. Medical treatment performed by a veterinarian involves inducing vomiting within two hours of ingestion and administration of benzodiazepines or barbiturates for seizures, antiarrhythmics for heart arrhythmias, and fluid diuresis. Theobromine is also suspected to induce right atrial cardiomyopathy after long term exposure at levels equivalent to approximately 15 g/kg of dark chocolate per day. According to the Merck Veterinary Manual, baker's chocolate of approximately 1.3 g/kg of a dog's body weight is sufficient to cause symptoms of toxicity. For example, 0.4 oz of baker's chocolate would be enough to produce mild symptoms in a 20 lb dog, while a 25% cacao chocolate bar (like milk chocolate) would be only 25% as toxic as the same dose of baker's chocolate. One ounce of milk chocolate per pound of body weight (1 oz/lb) is a potentially lethal dose in dogs.

Wildlife
In 2014, four American black bears were found dead at a bait site in New Hampshire. A necropsy and toxicology report performed at the University of New Hampshire in 2015 confirmed they died of heart failure caused by theobromine after they consumed 90 lb of chocolate and doughnuts placed at the site as bait. A similar incident killed a black bear cub in Michigan in 2011.

Pest control
In previous research, the USDA investigated the possible use of theobromine as a toxicant to control coyotes preying on livestock.