U.S. Route 395 Business

U.S. Route 395 Business may refer to:
 * U.S. Route 395 Business (Carson City, Nevada), running through downtown Carson City, Nevada
 * U.S. Route 395 Business (Reno, Nevada), running through Reno, Nevada
 * U.S. Route 395 Business (Ridgecrest, California), running through Ridgecrest, California