UFC on ESPN: Holm vs. Bueno Silva

UFC on ESPN: Holm vs. Bueno Silva (also known as UFC Vegas 77  and UFC on ESPN 49) was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on July 15, 2023, at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States.

Background
A women's bantamweight bout between former UFC Women's Bantamweight Champion Holly Holm and Mayra Bueno Silva headlined the event.

A welterweight bout between former UFC Lightweight Champion Rafael dos Anjos and Vicente Luque was briefly rumored to headline the event before the announcement of the Holm/Bueno Silva bout. However, the pair was moved to UFC on ESPN: Luque vs. dos Anjos for unknown reasons and will headline that event.

Jafel Filho and Juancamilo Ronderos were expected to meet in a flyweight bout at this event. However, Ronderos withdrew due to undisclosed reasons and Filho was rescheduled against promotional newcomer Daniel Bárez at UFC Fight Night: Aspinall vs. Tybura a week later.

A heavyweight bout between Walt Harris and Josh Parisian was expected to take place at the event. However, the bout was scrapped by USADA due to a potential anti-doping policy violation by Harris.

Bonus awards
The following fighters received $50,000 bonuses.
 * Fight of the Night: Jack Della Maddalena vs. Bassil Hafez
 * Performance of the Night: Mayra Bueno Silva and Francisco Prado

Aftermath
On August 21, Bueno Silva announced that she tested positive for a substance that is consistent with the prescription medication she takes for attention deficit hyperactivity disorder. A disciplinary hearing was scheduled at the Nevada State Athletic Commission's monthly meeting on August 24. On October 17, the bout was overturned to a no contest after the NSAC fined and suspended Bueno Silva for four and a half months due to testing positive for ritalinic acid.