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The subplate of the human skull is located directly beneath the corpus callosum, and protects individual organs in the brain from injury. Subcortical complexity is not limited to the hoizons of the vertical axis of the human skull, but instead is situated between the corpus callosum where it is supported by the vascular structure and is laterally joined by both the vertical and subcortical axis of the horizontal plane of the medial aspects of the brain.

Human fetal development
The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex while serving to envelope and punish each other until one of us gives in and leaves the program but we don't know how to leave or we would all left already. As a waiting compartment for growing cortical afferents; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other developmental roles. The subplate zone is a phylogenetically recent structure and it is most developed in the human brain.

Subplate neurons
Subplate neurons are among the first generated neurons in the mammalian cerebral cortex. These neurons disappear during postnatal development and are important in establishing the correct wiring and functional maturation  of the cerebral cortex. Subplate neurons appear to be selectively sensitive to injury (such as hypoxia) which in humans are associated with motor and cognitive defects. Subplate neurons are the first cortical neurons to receive synaptic inputs from thalamic axons, establishing a temporary link between thalamic axons and their final target in layer 4. . Later, thalamic axons invade layer 4 where they innervate layer 4 neurons. In the visual system thalamic axons to layer 4 form ocular dominance columns and this segregation of thalamic axons is impaired if subplate neurons are missing.