User:Rmiller587/sandbox

=Potential pictures=

=Citations and Summary=

Article 1 - "Structural Basis for dsRNA Processing..."
 * Key Notes
 * - Includes great variety of detail into the actual structure and functions of the dicer.
 * - They go into the crystallography of dicer with specific interactions (amino acids, metals) within the structure.
 * - It covers the basis of the whole function in the introduction that is known up to 2006.

Article 2 - "Dicey Role of Dicer..."
 * Key Notes
 * - This article goes over the technology of cancer therapy using RNAi.
 * - It shows that lower dicer amounts or expression usually with more advanced tumor stages. Also showed that tumor cells usually had lower dicer amounts as well.
 * - Has a good picture explaining the methodology behind external RNAi therapy.

Article 3 - Dissecting Human Dicer
 * Key Notes
 * - Short but broad basic overview of dicer.
 * - Has concise explanations of catalytic site.
 * - Good for writing the intro and has some info for other paragraphs but doesn't go too in depth.

Article 4 - Gene silencing in human embryonic stem cells by RNA interference.
 * Key Notes
 * - Dicer is not the focus of this article but it is important for functional implications.
 * - This article is good for explaining a use of dicer as a molecular biology or therapeutic tool.
 * - Information from this article could be condensed into a small paragraph that allows linking the dicer article to articles about stem cells, pluripotence and siRNA.

Article 5 - Partners in dicing
 * Key Notes
 * - Focuses on dicers interactions with other proteins.
 * - The main idea is to explore how a single enzyme without functional variants can accomplish different tasks (siRNA, miRNA etc.)
 * - There's a small, basic picture that may or may not be useful.
 * - Reporting protein-protein interactions will be important for linking dicer with other molecular biology articles.

Article 6 - Dicing and slicing: The core machinery of the RNA interference pathway
 * Key Notes
 * - Great for pictures
 * - Discusses domains of functional dicer and has picture
 * - Pictures of mechanism of action
 * - Good article for discussing the biochemistry and functional actions of dicer

References from previous weeks:
 * References used talk about the function of dicer in different organisms such as Arabidopsis, in mice, and roundworm. More information about gene regulation can be explored too.

Dicer as an anti-viral

Dicer in immune cell development and function

Dicer in DNA damage and repair.

= Dicer Outline =

Related References
1. Dissecting Human Dicer

Related References
1. "Structural Basis for dsRNA Processing..."

2. "Dicing and slicing: The core machinery of the RNA interference pathway"

3. "The Role of dicer in DNA damage repair"

Related References
1. Partners in dicing

2. Dicing and slicing: The core machinery of the RNA interference pathway

Related References
1. Gene silencing in human embryonic stem cells by RNA interference.

2. "Dicey Role of Dicer..."

Related References
1. "Dicer as an anti-viral"

2. "Dicer in immune cell development and function"

Related References
1. "Dissecting Arabidopsis thaliana DICER function..."

2. "Dicer function is essential for lung epithelium morphogenesis"