User:Tomato 33/aorta

The aorta is the largest artery in the human body, it receives all the oxygen-rich blood that is pumped from the left chamber (or ventricle) of the heart and extends down to the abdomen. From the aorta blood is distributed to every organ, with the exception of the lungs. Just like a big river with tributaries, the aorta splits multiple times.

Parts
In anatomical sources, the aorta is usually divided into sections.

One way of classifying a part of the aorta is by course and the direction of blood flow. In this system, the aorta starts as the ascending aorta (or ascending part of the aorta), taking a superior course from the heart, but then making a hairpin turn, the aortic arch or arch of aorta. The part after this hairpin turn takes an inferior course and is known as the descending aorta. The descending aorta is divided into two parts. The aorta begins to descend in the thoraic cavity, and consequently is known as the thoracic aorta. After the aorta passes through the diaphragm, it is known as the abdominal aorta. The aorta ends by dividing into two major blood vessels, the common iliac arteries and a smaller midline vessel, the median sacral artery.

Another way of classifying a part of the aorta is by anatomical compartment, where the thoracic aorta (or thoracic part of the aorta) runs from the heart to the thoracic diaphragm. The aorta then continues as the abdominal aorta (or abdominal part of the aorta) diaphragm to the aortic bifurcation.

In the next section the course and the direction of blood flow method is used.

Ascending aorta
The ascending aorta originates at the opening of the aortic valve at the heart. It runs in a common pericardial sheath with the pulmonary trunk. These two blood vessels twist around each other, causing the aorta to start out posterior to the pulmonary trunk, but ends by twisting to its right and anterior side. The transition from ascending aorta to aortic arch is at the pericardial reflection on the aorta.

At the root of the ascending aorta, the lumen has three little pockets between the cusps of the aortic valve and the wall of the aorta, named the aortic sinuses or sinuses of Valsalva. The left aortic sinus contains the origin of the left coronary artery and the right aortic sinus likewise gives rise to the right coronary artery. Together, these two arteries supply the heart. The posterior aortic sinus does not give rise to a coronary artery. For this reason the left, right and posterior aortic sinuses are also called left-coronary, right-coronary and non-coronary sinuses.

Aortic arch
The aortic arch loops over the right pulmonary artery and the bifurcation of the pulmonary trunk, with which it remains connected by the ligamentum arteriosum, a remnant of the fetal circulation that is obliterated a few days after birth. In addition to these blood vessels, the aortic arch crosses the left main bronchus. Between it and the pulmonary trunk is a network of autonomic nerve fibers, the cardiac or aortic plexus. The left vagus nerve, which passes anterior to the aortic arch, gives off a major branch, the recurrent laryngeal nerve, which loops under the aortic arch just lateral to the ligamentum arteriosum. It then runs back to the neck.

The aortic arch has three major branches: from proximal to distal they are the brachiocephalic trunk, which supplies the right side of the head and neck, as well as the right arm and chest wall, the left common carotid artery, and the left subclavian artery. The latter two together supply the left side of the same regions.

At the level of the intervertebral disc between the fourth and fifth thoracic vertebrae, the aortic arch ends and the descending aorta starts.

Descending aorta
The descending aorta is split up into two parts, the thoracic descending aorta and the abdominal aorta.

Thoracic descending aorta
The thoracic descending aorta gives rise to the intercostal and subcostal arteries, as well as to the superior and inferior left bronchial arteries and variable branches to the oesophagus, mediastinum, and pericardium. Its lowest pair of branches are the superior phrenic arteries, which supply the diaphragm, and the subcostal arteries for the twelfth rib.

Abdominal aorta
The abdominal aorta gives rise to lumbar and musculophrenic arteries, renal and middle suprarenal arteries, and visceral arteries (the celiac trunk, the superior mesenteric artery and the inferior mesenteric artery). It ends in a bifurcation into the left and right common iliac arteries. At the point of the bifurcation, there also springs a smaller branch, the median sacral artery.

Development
At the start of embryological development in mammals and birds, the aorta is split up into multiple arteries called aortic arches. There are 6 aortic arches to start with, but after development only the third, the fourth and the sixth survive. The third aortic arch vessel persists as the brachiocephalic artery (also called the root of the internal carotid). The fourth aortic arch vessel becomes the arch of the aorta and the sixth arch contributes to the pulmonary arteries. All great arteries, including the aorta, are made out of smooth muscle cells. Usually the muscle cells are derived from the mesoderm, but these muscle cells are formed by Cardiac Neural Crest Cells (CNCCs). These CNCCs are temporary multipotent (can give rise to some other types of cells but not all) cells that are pinched off during the formation of the neural tube (precursor to the spinal cord and brain) that have migrated to the aortic arches. These cells also form the aorticopulmonary septum which separates the aorta and pulmonary artery. A failure of the aorticopulmonary septum to divide the great vessels results in persistent truncus arteriosus, a heart condition where the two chambers are connected.

Histology
The aorta consists of a heterogeneous mixture of smooth muscle, nerves, intimal cells, endothelial cells, fibroblast-like cells, and a complex extracellular matrix. The vascular wall consists of several layers known as the tunica adventitia, tunica media, and tunica intima. The thickness of the aorta encourages an extensive network of tiny blood vessels called vasa vasorum, which feed the outer layers of the aorta. The aortic arch contains baroreceptors and chemoreceptors that relay information concerning blood pressure, blood pH and carbon dioxide levels to the medulla oblongata of the brain. This information is processed by the brain and the autonomic nervous system mediates the homeostatic responses.

Within the tunica media, smooth muscle and the extracellular matrix are quantitatively the largest components of the aortic vascular wall. This layer of the aorta consist of concentric musculoelastic layers (the elastic lamella) in mammals. The smooth muscle component does not dramatically alter the diameter of the aorta but rather serves to increase the stiffness and viscoelasticity of the aortic wall when activated. The elastic matrix dominates the biomechanical properties of the aorta. The elastic matrix forms lamella, consisting of elastic fibers, collagens(predominately type III), proteoglycans, and glycoaminoglycans.

Variations
Variations may occur in the location of the aorta, and the way in which arteries branch off the aorta. The aorta, normally on the left side of the body, may be found on the right in dextrocardia, in which the heart is found on the right, or situs inversus, in which the location of all organs are flipped.

Variations in the branching of individual arteries may also occur. For example, the left vertebral artery may arise from the aorta, instead of the left common carotid.

Function
The aorta supplies all of the systemic circulation, which means that the entire body, except for the respiratory zone of the lung gets its blood from the aorta. Broadly speaking, branches from the ascending aorta supply the heart, branches from the aortic arch supply the head, neck and arms, branches from the thoracic descending aorta supply the chest (excluding the heart and the respiratory zone of the lung) and branches from the abdominal aorta supply the abdomen. The pelvis and legs get their blood from the common iliac arteries.

Blood flow and velocity
The aorta is an elastic artery, and as such is quite stretchable. This is needed because Mean arterial blood pressure is the highest in the aorta. When the left ventricle contracts to force blood into the aorta, the aorta expands. This stretching gives the potential energy that will help maintain blood pressure during diastole, as during this time the aorta contracts passively. This is called the Windkessel effect. Mean arterial pressure diminishes across the circulation; from aorta to arteries to arterioles to capillaries to veins back to the atrium. The pulsatile nature of blood flow (caused by a beat of the heart) also creates a pulse wave that is propagated down the arterial tree. At the bifurcations reflected waves rebound to return to semilunar valves at the heart. These return waves create the dicrotic notch displayed in the aortic pressure curve during the cardiac cycle as these reflected waves push on the aortic semilunar valve. With age, the aorta stiffens such that the pulse wave is propagated faster and reflected waves return to the heart faster before the semilunar valve closes, which raises the blood pressure. The stiffness of the aorta is associated with a number of diseases and pathologies, and noninvasive measures of the pulse wave velocity are an independent indicator of hypertension. Measuring the pulse wave velocity (invasively and non-invasively) is a means of determining arterial stiffness. Maximum aortic velocity may be noted as Vmax or less commonly as AoVmax.

Clinical relevance

 * Aortic aneurysm – myotic, bacterial (e.g. syphilis), senile, genetic, associated with valvular heart disease
 * Aortic dissection
 * Aortic coarctation – pre-ductal, post-ductal
 * Transposition of the great vessels, see also dextro-Transposition of the great arteries and levo-Transposition of the great arteries
 * Atherosclerosis
 * Marfan syndrome
 * Ehlers–Danlos syndrome
 * Aortic stenosis
 * Trauma, such as traumatic aortic rupture, most often thoracic and distal to the left subclavian artery and frequently quickly fatal

In other animals
All amniotes have a broadly similar arrangement to that of humans, albeit with a number of individual variations. In fish, however, there are two separate vessels referred to as aortas. The ventral aorta carries de-oxygenated blood from the heart to the gills; part of this vessel forms the ascending aorta in tetrapods (the remainder forms the pulmonary artery). A second, dorsal aorta carries oxygenated blood from the gills to the rest of the body, and is homologous with the descending aorta of tetrapods. The two aortas are connected by a number of vessels, one passing through each of the gills. Amphibians also retain the fifth connecting vessel, so that the aorta has two parallel arches.

History
The word 'Aorta' stems from the Late Latin aorta from aortē (ἀορτή), from aeirō, "I lift, raise" (ἀείρω) This term was first applied by Aristotle when describing the aorta.