VAV2

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.

Interactions
VAV2 is a GEF for RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation. Double DH domain mutations, L342R/L343SVav2 function as a dominant negative, blocking VAV2 GEF activity for RAC1 and a PH domain mutant is required for recruitment of VAV2 to the membrane in order to elicit GEF activity. VAV2 has also been shown to regulate collagen phagocytosis in a RAC1-dependent manner and interact with CD19 and Grb2.