William Sadler

William Sadler may refer to:


 * William Sadler (painter) (c.1782–1839), Irish landscape painter
 * William Sadler (Medal of Honor) (1854–?), American sailor and Medal of Honor recipient
 * William Sadler (actor) (born 1950), American film and television actor
 * William S. Sadler (1875–1969), American surgeon and psychiatrist
 * Billy Sadler (born 1981), American baseball pitcher
 * William "Bubby" Sadler (1909-1987), American Negro league baseball player
 * William George "Bill" Sadler (born 1931), Canadian race car designer, electrical and electronics engineer, aviation designer.