1921 Oklahoma Sooners football team

The 1921 Oklahoma Sooners football team represented the University of Oklahoma in the 1921 college football season. In their 17th year under head coach Bennie Owen, the Sooners compiled a 5–3 record (2-3 against conference opponents), finished in a tie for seventh place in the Missouri Valley Intercollegiate Athletic Association (MVIAA), and outscored their opponents by a combined total of 127 to 102.

No Sooners were recognized as All-Americans, and end Howard Marsh was the only Sooner to receive all-conference honors.