1980–81 Cupa României

The 1980–81 Cupa României was the 43rd edition of Romania's most prestigious football cup competition.

The title was won by Universitatea Craiova against Politehnica Timişoara.

Format
The competition is an annual knockout tournament.

First round proper matches are played on the ground of the lowest ranked team, then from the second round proper the matches are played on a neutral location.

In the first round proper, if a match is drawn after 90 minutes, the game goes in extra time, if the scored is still tight after 120 minutes, the team who played away will qualify, if the teams are from the same league, then the winner will be established at penalty kicks.

From the second round proper, if a match is drawn after 90 minutes, the game goes in extra time, if the scored is still tight after 120 minutes, then the winner will be established at penalty kicks.

From the first edition, the teams from Divizia A entered in competition in sixteen finals, rule which remained till today.

First round proper

 * colspan=3 style="background-color:#FFCCCC;"|26 November 1980

Second round proper

 * colspan=3 style="background-color:#FFCCCC;"|3 December 1980

Quarter-finals

 * colspan=3 style="background-color:#FFCCCC;"|4 March 1981

Semi-finals

 * colspan=3 style="background-color:#FFCCCC;"|20 May 1981