1980 U.S. Pro Indoor – Singles

Jimmy Connors was the defending champion.

Connors successfully defended his title, defeating John McEnroe, 6–3, 2–6, 6–3, 3–6, 6–4 in the final.

Seeds

 * 1) 🇺🇸 Jimmy Connors (champion)
 * 2) 🇺🇸 John McEnroe (final)
 * 3) 🇺🇸 Vitas Gerulaitis (second round)
 * 4) N/A
 * 5) 🇺🇸 Harold Solomon (quarterfinals)
 * 6) 🇪🇸 José Higueras (third round)
 * 7) 🇺🇸 Gene Mayer (semifinals)
 * 8) 🇺🇸 Peter Fleming (second round)
 * 9) 🇵🇱 Wojtek Fibak (quarterfinals)
 * 10) 🇦🇷 José Luis Clerc (quarterfinals)
 * 11) 🇺🇸 Brian Gottfried (third round)
 * 12) N/A
 * 13) 🇺🇸 Stan Smith (third round)
 * 14) 🇺🇸 Victor Amaya (second round)
 * 15) 🇫🇷 Yannick Noah (first round)
 * 16) 🇺🇸 Tim Gullikson (third round)