1981 U.S. Pro Indoor – Singles

Jimmy Connors was the defending champion, but lost in the quarterfinals this year.

Roscoe Tanner won the title, defeating Wojtek Fibak, 6–2, 7–6, 7–5 in the final.

Seeds
• # 🇺🇸 Jimmy Connors (quarterfinals)

• # 🇺🇸 Harold Solomon (third round)

• # 🇺🇸 Vitas Gerulaitis (quarterfinals)

• # 🇺🇸 Eliot Teltscher (first round)

• # 🇺🇸 Brian Gottfried (second round)

• # 🇺🇸 Brian Teacher (second round)

• # 🇺🇸 Roscoe Tanner (champion)

• # 🇵🇱 Wojtek Fibak (final)

• # 🇺🇸 Victor Amaya (third round, retired)

• # Johan Kriek (first round)

• # 🇺🇸 John Sadri (quarterfinals)

• # 🇭🇺 Balázs Taróczy (third round)

• # 🇮🇳 Vijay Amritraj (second round)

• # 🇫🇷 Yannick Noah (semifinals)

• # 🇺🇸 Bill Scanlon (first round)

• # Tomáš Šmíd (second round)