1991–92 European Cup second round

The 1991–92 European Cup second round was the second stage of the 1991–92 European Cup competition, and featured the 16 teams that advanced from the first round. It began on 23 October with the first legs and ended on 6 November 1991 with the second legs. The eight winners advanced to the group stage.

Times are CET (UTC+1), as listed by UEFA.

Format
Each tie was played over two legs, with each team playing one leg at home. The team that scored more goals on aggregate over the two legs advanced to the next round. If the aggregate score was level, the away goals rule was applied, i.e. the team that scored more goals away from home over the two legs advanced. If away goals were also equal, then extra time was played. The away goals rule would be again applied after extra time, i.e. if there were goals scored during extra time and the aggregate score was still level, the visiting team advanced by virtue of more away goals scored. If no goals were scored during extra time, the tie was decided by penalty shoot-out.

Draw
The draw for the second round was held on 4 October 1991 in Geneva, Switzerland.

Summary
 The first legs were played on 23 October, and the second legs on 6 November 1991.


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Matches
3–3 on aggregate; Barcelona won on away goals.

4–4 on aggregate; Sparta Prague won on away goals.

Benfica won 4–2 on aggregate.

Dynamo Kyiv won 2–1 on aggregate.

Panathinaikos won 4–2 on aggregate.

Anderlecht won 2–0 on aggregate.

Red Star Belgrade won 5–1 on aggregate.

Sampdoria won 4–3 on aggregate.