2008 ECM Prague Open – Women's singles

The women's singles of the 2008 ECM Prague Open tournament was played on clay in Prague, Czech Republic.

Akiko Morigami was the defending champion, but chose not to participate that year.

Vera Zvonareva won in the final 7–6(2), 6–2, against Victoria Azarenka.

Seeds
• # 🇷🇺 Vera Zvonareva (champion)

• # 🇮🇱 Shahar Pe'er (quarterfinals)

• # 🇧🇾 Victoria Azarenka (final)

• # Katarina Srebotnik (semifinals)

• # 🇮🇹 Karin Knapp (first round)

• # Michaëlla Krajicek (first round)

• # 🇨🇿 Klára Zakopalová (semifinals)

• # 🇪🇪 Kaia Kanepi (second round)