2010 Charleston Southern Buccaneers football team

The 2010 Charleston Southern Buccaneers football team represented Charleston Southern University as a member of the Big South Conference during the 2010 NCAA Division I FCS football season. Led by eighth-year head coach Jay Mills, the Buccaneers compiled an overall record of 3–8 with a mark of 1–5 in conference play, and tied for last in the Big South.