2010 Copa Petrobras São Paulo – Singles

Thomaz Bellucci was the defending champion, however he lost in the final to his compatriot Marcos Daniel in three sets (1–6, 6–3, 3–6).

Seeds
• # 🇧🇷 Thomaz Bellucci (final)

• # 🇪🇸 Rubén Ramírez Hidalgo (first round)

• # Rui Machado (quarterfinals)

• # 🇧🇷 João Souza (first round)

• # 🇪🇸 Albert Ramos-Viñolas (first round)

• # Nicolás Massú (second round)

• # 🇰🇿 Yuri Schukin (quarterfinals)

• # 🇪🇸 Daniel Muñoz-de la Nava (first round)