2010 Knoxville Challenger

The 2010 Knoxville Challenger was a professional tennis tournament played on outdoor hard courts. It was the seventh edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Knoxville, Tennessee, United States between 8 and 14 November 2010.

Seeds

 * Rankings are as of November 1, 2010.

Other entrants
The following players received wildcards into the singles main draw:
 * 🇷🇸 Boris Čonkić
 * 🇺🇸 Eric Quigley
 * 🇦🇺 John-Patrick Smith
 * 🇺🇸 Rhyne Williams

The following players received entry from the qualifying draw:
 * 🇮🇳 Yuki Bhambri
 * Luka Gregorc
 * 🇺🇸 David Martin
 * 🇺🇸 Nicholas Monroe
 * Fritz Wolmarans (LL)

Singles
🇯🇵 Kei Nishikori def. 🇺🇸 Robert Kendrick, 6–1, 6–4

Doubles
Rik de Voest / Izak van der Merwe def. 🇺🇸 Alex Bogomolov Jr. / 🇺🇸 Alex Kuznetsov, 6–1, 6–4