2012 Comerica Bank Challenger – Singles

Laurynas Grigelis, the defending champion, didn't participate this year. Steve Johnson won the title, defeating Robert Farah 6–3, 6–3 in the final.

Seeds
• # 🇺🇸 Brian Baker (first round)

• # 🇷🇺 Igor Andreev (first round)

• # 🇺🇸 Rajeev Ram (first round)

• # Igor Sijsling (withdrew due to gastroenteritis)

• # 🇩🇪 Tobias Kamke (first round)

• # 🇫🇷 Florent Serra (second round)

• # Izak van der Merwe (first round)

• # 🇺🇸 Denis Kudla (first round)