2012 Odlum Brown Vancouver Open – Women's singles

Aleksandra Wozniak was the defending champion, but qualified for the 2012 Summer Olympics.

Mallory Burdette won the title, defeating Jessica Pegula 6–3, 6–0 in the final.

Seeds
• # 🇱🇺 Mandy Minella (first round)

• # 🇦🇺 Olivia Rogowska (quarterfinals)

• # 🇺🇸 Alexa Glatch (first round)

• # 🇵🇱 Sandra Zaniewska (first round, retired)

• # 🇺🇸 Madison Brengle (first round)

• # 🇦🇺 Sacha Jones (first round)

• # 🇺🇸 Grace Min (withdrew)

• # 🇺🇸 Madison Keys (quarterfinals)