2015 Knoxville Challenger – Singles

Adrian Mannarino was the defending champion, but chose not to compete this year.

Daniel Evans won the title, defeating Frances Tiafoe in the final 5–7, 6–1, 6–3.

Seeds
• # 🇹🇳 Malek Jaziri (first round)

• # 🇺🇸 Austin Krajicek (second round)

• # 🇺🇸 Tim Smyczek (second round)

• # 🇺🇸 Ryan Harrison (first round)

• # 🇦🇺 James Duckworth (quarterfinals)

• # 🇦🇺 John-Patrick Smith (second round)

• # 🇨🇴 Alejandro Falla (first round)

• # Blaž Rola (second round)