2018 Knoxville Challenger – Doubles

Leander Paes and Purav Raja were the defending champions but only Paes chose to defend his title, partnering Miguel Ángel Reyes-Varela. Paes lost in the quarterfinals to Alex Lawson and Jackson Withrow.

Toshihide Matsui and Frederik Nielsen won the title after defeating Hunter Reese and Tennys Sandgren 7–6(8–6), 7–5 in the final.

Seeds
• # 🇮🇳 Leander Paes / 🇲🇽 Miguel Ángel Reyes-Varela (quarterfinals)

• # Marcelo Arévalo / 🇻🇪 Roberto Maytín (first round)

• # 🇦🇺 Matt Reid / 🇦🇺 John-Patrick Smith (first round)

• # 🇪🇸 Marcel Granollers / Mark Vervoort (first round)