2019 NPSL season

The 2019 National Premier Soccer League season is part of the 107th season of FIFA-sanctioned soccer in the United States and the 17th season of the National Premier Soccer League (NPSL). Miami FC, formerly "Miami FC 2," are the defending champion.

Changes from 2018
Six members of the NPSL will participate in the inaugural NPSL Members Cup tournament immediately following the 2019 regular season.

Keystone Conference playoffs
Bold = winner * = after extra time, = penalty shootout score

Mid-Atlantic Conference playoffs
Bold = winner * = after extra time, = penalty shootout score

North Atlantic Conference playoffs
Bold = winner * = after extra time, = penalty shootout score

Southeast Conference playoffs
Bold = winner * = after extra time, = penalty shootout score

Sunshine Conference playoffs
Bold = winner * = after extra time, = penalty shootout score

Lone Star Conference playoffs
Bold = winner * = after extra time, = penalty shootout score

Heartland Conference playoffs
Bold = winner * = after extra time, = penalty shootout score

Regional and National playoffs
Bold = winner * = after extra time,  = penalty shootout score

Regional Semifinals

 * note= New York Cosmos B had a bye to the Finals

Members Cup
Six teams participated in the NPSL Members Cup, formerly known as the NPSL Founders Cup, a competition that ran from August to October 2019 after the conclusion of the regular 2019 NPSL season. It was intended to lead to a new professional league beginning play in the spring of 2020.

Several other clubs were initially announced to be part of the tournament. California United Strikers FC officially announced on Twitter that it had withdrawn from both the Founders Cup and subsequent league on March 1, 2019 and were replaced by Napa Valley 1839 FC on March 7, 2019. On June 27, 2019, Oakland Roots SC announced its intent to join the upcoming National Independent Soccer Association (NISA) in fall 2019, where they joined Cal United. They would therefore be dropping out of the tournament "to focus on NISA as (their) preferred path forward."

When the competition officially re-branded on July 24, 2019, ASC San Diego, Cal FC, FC Arizona, Miami FC, and Miami United FC had been removed, Miami FC joining NISA, while the Michigan Stars FC had been added. On August 15, Chattanooga and Detroit City were both announced to be joining NISA in the spring of 2020. Michigan Stars were also confirmed to be joining NISA on September 21. And New York Cosmos ended up later joining, in 2020.