2019 Open Città della Disfida – Singles

Marco Trungelliti was the defending champion but chose not to defend his title.

Gianluca Mager won the title after Nikola Milojević retired at 7–6(9–7), 5–7, 3–2 in the final.

Seeds
All seeds receive a bye into the second round. • # 🇮🇹 Gianluigi Quinzi (third round)

• # 🇩🇪 Oscar Otte (third round)

• # 🇮🇹 Stefano Travaglia (third round)

• # 🇮🇹 Filippo Baldi (third round)

• # 🇮🇹 Alessandro Giannessi (withdrew)

• # 🇮🇹 Lorenzo Giustino (third round)

• # 🇮🇹 Andrea Arnaboldi (third round, retired)

• # 🇮🇹 Gianluca Mager (champion)

• # 🇷🇸 Nikola Milojević (final, retired)

• # 🇦🇺 Thanasi Kokkinakis (third round, withdrew)

• # 🇦🇹 Jurij Rodionov (second round)

• # 🇸🇰 Filip Horanský (quarterfinals)

• # 🇮🇹 Stefano Napolitano (quarterfinals)

• # Viktor Galović (semifinals)

• # 🇩🇪 Mats Moraing (second round)

• # 🇪🇬 Mohamed Safwat (semifinals)