2019 San Luis Open Challenger Tour – Singles

Marcelo Arévalo was the defending champion but lost in the second round to Marcelo Tomás Barrios Vera.

Marc-Andrea Hüsler won the title after defeating Adrián Menéndez Maceiras 7–5, 7–6(7–3) in the final.

Seeds
All seeds receive a bye into the second round. • # 🇰🇿 Alexander Bublik (third round)

• # 🇪🇸 Adrián Menéndez Maceiras (final)

• # 🇩🇪 Dustin Brown (second round)

• # 🇦🇹 Sebastian Ofner (second round)

• # 🇧🇦 Mirza Bašić (second round)

• # 🇪🇨 Roberto Quiroz (third round)

• # 🇷🇸 Peđa Krstin (second round)

• # 🇪🇬 Mohamed Safwat (second round)

• # 🇦🇺 John-Patrick Smith (second round)

• # Blaž Rola (second round)

• # 🇦🇹 Lucas Miedler (quarterfinals)

• # Marcelo Arévalo (second round)

• # Scott Griekspoor (second round)

• # 🇪🇸 Roberto Ortega Olmedo (second round)

• # 🇩🇴 Roberto Cid Subervi (second round)

• # 🇷🇸 Danilo Petrović (second round)