2022 San Luis Open Challenger – Singles

Marc-Andrea Hüsler was the defending champion but lost in the semifinals to Antoine Bellier.

Bellier won the title after defeating Renzo Olivo 6–7(2–7), 6–4, 7–5 in the final.

Seeds
• # 🇸🇰 Andrej Martin (quarterfinals)

• # Nicolás Jarry (semifinals)

• # 🇺🇸 Ernesto Escobedo (quarterfinals)

• # 🇦🇷 Facundo Mena (first round)

• # 🇬🇧 Jay Clarke (second round)

• # Marc-Andrea Hüsler (semifinals)

• # 🇮🇹 Federico Gaio (second round)

• # 🇦🇷 Renzo Olivo (final)