2019 Uruguay Open – Singles

Guido Pella was the defending champion but chose not to defend his title.

Jaume Munar won the title after defeating Federico Delbonis 7–5, 6–2 in the final.

Seeds
All seeds receive a bye into the second round. • # Pablo Cuevas (third round)

• # 🇧🇴 Hugo Dellien (quarterfinals)

• # 🇦🇷 Federico Delbonis (final)

• # 🇧🇷 Thiago Monteiro (second round)

• # 🇪🇸 Jaume Munar (champion)

• # 🇸🇰 Andrej Martin (quarterfinals)

• # 🇦🇷 Federico Coria (third round)

• # 🇦🇷 Facundo Bagnis (quarterfinals)

• # 🇵🇪 Juan Pablo Varillas (second round)

• # 🇪🇸 Mario Vilella Martínez (third round, retired)

• # 🇸🇰 Jozef Kovalík (third round)

• # 🇩🇪 Yannick Hanfmann (second round)

• # 🇧🇷 João Menezes (second round)

• # João Domingues (third round)

• # 🇦🇷 Facundo Mena (third round)

• # 🇦🇷 Andrea Collarini (quarterfinals)