2020–21 Missouri State Lady Bears basketball team

The 2020–21 Missouri State Lady Bears basketball team represented Missouri State University during the 2020–21 NCAA Division I women's basketball season. The Lady Bears, led by second year head coach Amaka Agugua-Hamilton, played their home games at JQH Arena and were members of the Missouri Valley Conference.

They finished the season 23–3 and 16–0 in conference play to finish as Missouri Valley Conference champions. As the first seed in the Missouri Valley tournament, they defeated in the quarterfinals before having to forfeit their semifinal game. They received an at-large bid to the NCAA tournament and were the fifth seed in the Alamo Regional. They defeated twelve seed and thirteen seed  before falling to the first seed Stanford in the Sweet Sixteen.

Previous season
The Lady Bears finished the season 26–4, 16–2 in MVC play to finish in first place. The Missouri Valley tournament and NCAA tournament were cancelled due to the COVID-19 outbreak.

Schedule
Source:

!colspan=6 style=| Non-conference regular season

!colspan=6 style=| Missouri Valley Conference Season

!colspan=6 style=| Missouri Valley women's tournament

!colspan=6 style=| NCAA tournament

Rankings
The Coaches Poll did not release a Week 2 poll and the AP Poll did not release a poll after the NCAA Tournament.