2020–21 Moldovan National Division

The 2020–21 Moldovan National Division (Divizia Națională) was the 30th season of top-tier football in Moldova. The season started on 3 July 2020 and ended on 26 May 2021. Sheriff Tiraspol were the defending champions. The winners of the league this season earned a spot in the first qualifying round of the 2021–22 UEFA Champions League, and the second, third and fourth placed clubs earned a place in the first qualifying round of the 2021–22 UEFA Europa Conference League.

Teams
A total of 10 teams competing in the league. These include 8 teams from the 2019 season and two promoted teams from the "A" Division: Florești and Dacia Buiucani, both making their debut in the top flight.

Results
Teams will play each other four times (twice at home, twice away).

Results by round
The following table represents the teams game results in each round.