2020–21 Southern Miss Golden Eagles basketball team

The 2020–21 Southern Miss Golden Eagles basketball team represented the University of Southern Mississippi during the 2020–21 NCAA Division I men's basketball season. The team was led by second-year head coach Jay Ladner, and played their home games at Reed Green Coliseum in Hattiesburg, Mississippi as members of Conference USA.

Schedule and results
!colspan=12 style=|Non-conference regular season

!colspan=12 style=|CUSA regular season

!colspan=12 style=| Conference USA tournament