2020–21 TSG 1899 Hoffenheim season

The 2020–21 season was the 122nd season in the existence of TSG 1899 Hoffenheim and the club's 13th consecutive season in the top flight of German football. In addition to the domestic league, TSG 1899 Hoffenheim participated in this season's editions of the DFB-Pokal and in the UEFA Europa League. The season covered the period from 1 July 2020 to 30 June 2021. On 27 September 2020, on matchday 2 of Bundesliga season, Hoffenhiem ended Bayern Munich's 32 match winning run.

Matches
The league fixtures were announced on 7 August 2020.

Group stage
The group stage draw was held on 2 October 2020.

Round of 32
The draw for the round of 32 was held on 14 December 2020.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season