2021–22 Toronto Maple Leafs season

The 2021–22 Toronto Maple Leafs season was the 105th season for the National Hockey League franchise that was established on November 22, 1917. On April 9, 2022, the Maple Leafs clinched a playoff spot with a 3–2 win against the Montreal Canadiens. With a 4–2 win over the New York Islanders on April 17, the Maple Leafs set franchise records in both wins (50) and points (106). The Maple Leafs qualified for the playoffs for the sixth consecutive season, but they were upset in the first round by the two-time defending Stanley Cup champion Tampa Bay Lightning, losing in seven games, despite leading the series 3–2 with a 3–2 lead after the 2nd period of Game 6. After the Florida Panthers winning a playoff series for the first time since 1996, Toronto held the NHL's longest active playoff series win drought, not having won a playoff series since 2004.

Regular season

 * 2021–22 schedule
 * 2021–22 schedule

Goaltenders
(M) Player was playing for the minor league affiliate Toronto Marlies of the AHL at end of regular season (X) Player is no longer with the Maple Leafs organization (p) Player previously played with another team before being acquired by Toronto

Bold/italics denotes franchise record.

Transactions
The Maple Leafs have been involved in the following transactions during the 2021–22 season.

Draft picks
Below are the Toronto Maple Leafs' selections at the 2021 NHL Entry Draft, which were held on July 23 to 24, 2021. It was held virtually via video conference call from the NHL Network studio in Secaucus, New Jersey.