2021–22 U20 Andebol 1

The 2021–22 U20 Andebol 1 (Campeonato Nacional Séniores Sub-20 de Andebol 1) was the first season of Portuguese premier handball league for players under twenty years old. It ran from 17 October 2021 to 16 June 2022.

Águas Santas won its first trophies, and it becomes the first club to conquer the U20 Portuguese Handball Championship.

Teams
The teams contesting the 2021–22 U20 Andebol 1 season are: