2021 Almaty Challenger – Singles

Lorenzo Giustino was the defending champion but lost in the first round to Timofey Skatov.

Zizou Bergs won the title after defeating Skatov 4–6, 6–3, 6–2 in the final.

Seeds
• # 🇸🇰 Andrej Martin (quarterfinals)

• # 🇪🇬 Mohamed Safwat (first round)

• # 🇧🇪 Kimmer Coppejans (quarterfinals)

• # 🇫🇷 Enzo Couacaud (second round)

• # 🇮🇹 Lorenzo Giustino (first round)

• # 🇰🇿 Dmitry Popko (semifinals, retired)

• # 🇺🇿 Denis Istomin (second round)

• # 🇧🇷 João Menezes (second round)