2021 Amex-Istanbul Challenger II – Singles

Arthur Rinderknech was the defending champion but chose not to defend his title.

James Duckworth won the title after defeating Wu Tung-lin 6–4, 6–2 in the final.

Seeds
• # 🇦🇺 James Duckworth (champion)

• # 🇲🇩 Radu Albot (second round)

• # 🇨🇴 Daniel Elahi Galán (first round)

• # 🇯🇵 Yasutaka Uchiyama (quarterfinals)

• # 🇦🇺 Marc Polmans (second round)

• # 🇷🇺 Evgeny Donskoy (second round)

• # 🇺🇦 Illya Marchenko (second round)

• # 🇪🇬 Mohamed Safwat (withdrew)