2021 Andalucía Challenger – Singles

Pedro Martínez was the defending champion but chose not to defend his title.

Gianluca Mager won the title after defeating Jaume Munar 2–6, 6–3, 6–2 in the final.

Seeds
• # 🇪🇸 Roberto Carballés Baena (first round)

• # 🇸🇰 Norbert Gombos (first round)

• # 🇪🇸 Jaume Munar (final)

• # 🇮🇹 Gianluca Mager (champion)

• # Pedro Sousa (second round)

• # 🇯🇵 Taro Daniel (quarterfinals)

• # 🇧🇦 Damir Džumhur (second round)

• # 🇷🇺 Evgeny Donskoy (first round)