2021 Campeonato Internacional de Tênis de Campinas – Singles

Francisco Cerúndolo was the defending champion but lost in the semifinals to Sebastián Báez.

Báez won the title after defeating Thiago Monteiro 6–1, 6–4 in the final.

Seeds
• # 🇦🇷 Federico Coria (first round)

• # 🇪🇸 Jaume Munar (first round)

• # 🇦🇷 Juan Manuel Cerúndolo (quarterfinals)

• # 🇧🇷 Thiago Monteiro (final)

• # Pablo Cuevas (first round)

• # 🇨🇴 Daniel Elahi Galán (first round)

• # 🇦🇷 Sebastián Báez (champion)

• # 🇦🇷 Francisco Cerúndolo (semifinals)