2021 Cassis Open Provence – Singles

Jo-Wilfried Tsonga was the defending champion but chose not to defend his title.

Benjamin Bonzi won the title after defeating Lucas Pouille 7–6(7–4), 6–4 in the final.

Seeds
• # 🇫🇷 Benjamin Bonzi (champion)

• # 🇯🇵 Yasutaka Uchiyama (withdrew)

• # 🇦🇺 Christopher O'Connell (withdrew)

• # 🇰🇿 Mikhail Kukushkin (first round, retired)

• # 🇫🇷 Lucas Pouille (final)

• # 🇫🇷 Grégoire Barrère (first round)

• # 🇦🇹 Jurij Rodionov (first round)

• # 🇬🇧 Liam Broady (semifinals)