2022 Cassis Open Provence – Singles

Benjamin Bonzi was the defending champion but chose not to defend his title.

Hugo Grenier won the title after defeating James Duckworth 7–5, 6–4 in the final.

Seeds
• # 🇫🇷 Constant Lestienne (quarterfinals)

• # 🇦🇺 James Duckworth (final)

• # 🇫🇷 Hugo Grenier (champion)

• # 🇨🇿 Tomáš Macháč (semifinals)

• # 🇩🇪 Jan-Lennard Struff (second round)

• # 🇬🇧 Ryan Peniston (second round)

• # 🇭🇺 Zsombor Piros (quarterfinals)

• # 🇯🇵 Kaichi Uchida (quarterfinals)