2021 Engie Open Andrézieux-Bouthéon 42 – Singles

Ysaline Bonaventure was the defending champion, but chose not to participate.

Harmony Tan won the title, defeating Jaqueline Cristian in the final, 3–6, 6–2, 6–1.

Seeds
• # 🇫🇷 Océane Dodin (second round)

• # 🇩🇪 Anna-Lena Friedsam (quarterfinals)

• # Stefanie Vögele (second round)

• # 🇺🇦 Katarina Zavatska (quarterfinals)

• # 🇨🇿 Tereza Martincová (second round)

• # 🇩🇪 Tamara Korpatsch (first round)

• # 🇧🇬 Viktoriya Tomova (second round)

• # Clara Tauson (second round)