2021 Engie Open Nantes Atlantique – Singles

Cristina Bucșa was the defending champion but withdrew from the tournament.

Anhelina Kalinina won the title after Océane Dodin retired in the final at 7–6(7–4), 1–0.

Seeds
• # 🇺🇦 Anhelina Kalinina (champion)

• # 🇷🇺 Varvara Gracheva (quarterfinals)

• # 🇫🇷 Océane Dodin (final, retired)

• # 🇮🇹 Martina Trevisan (semifinals)

• # 🇷🇺 Kamilla Rakhimova (second round)

• # Polona Hercog (first round)

• # 🇷🇺 Vitalia Diatchenko (semifinals)

• # 🇨🇳 Zheng Qinwen (first round)