2021 Garden Open II – Singles

Andrea Pellegrino was the defending champion but lost in the quarterfinals to Flavio Cobolli.

Juan Manuel Cerúndolo won the title after defeating Cobolli 6–2, 3–6, 6–3 in the final.

Seeds
• # 🇧🇦 Damir Džumhur (first round)

• # 🇧🇴 Hugo Dellien (first round)

• # 🇮🇹 Federico Gaio (second round)

• # 🇷🇸 Danilo Petrović (second round)

• # 🇫🇷 Hugo Gaston (first round)

• # 🇮🇹 Paolo Lorenzi (first round)

• # 🇵🇪 Juan Pablo Varillas (first round)

• # 🇮🇹 Alessandro Giannessi (semifinals)