2021 Knoxville Challenger – Doubles

Hans Hach Verdugo and Adrián Menéndez Maceiras were the defending champions but only Hach Verdugo chose to defend his title, partnering Miguel Ángel Reyes-Varela. Hach Verdugo lost in the final to Malek Jaziri and Blaž Rola.

Jaziri and Rola won the title after defeating Hach Verdugo and Reyes-Varela 3–6, 6–3, [10–5] in the final.

Seeds
• # 🇲🇽 Hans Hach Verdugo / 🇲🇽 Miguel Ángel Reyes-Varela (final)

• # Treat Huey / Frederik Nielsen (first round)

• # 🇺🇸 Evan King / 🇺🇸 Hunter Reese (semifinals)

• # 🇺🇸 Robert Galloway / 🇺🇸 Alex Lawson (quarterfinals)