2021 Open Quimper Bretagne II – Singles

This event was the second edition of the Open Quimper Bretagne in 2021 after the Open d'Orléans was delayed due to the COVID-19 pandemic in France.

Sebastian Korda was the defending champion but withdrew before the tournament started due to injury. Brandon Nakashima won the title after defeating Bernabé Zapata Miralles 6–3, 6–4 in the final.

Seeds
• # 🇪🇸 Alejandro Davidovich Fokina (first round, retired)

• # 🇫🇷 Lucas Pouille (second round)

• # 🇺🇸 Sebastian Korda (withdrew)

• # 🇫🇷 Grégoire Barrère (first round)

• # 🇺🇸 Denis Kudla (first round)

• # 🇫🇷 Antoine Hoang (first round)

• # 🇫🇷 Arthur Rinderknech (second round)

• # 🇮🇹 Federico Gaio (quarterfinals)