2022 Open Quimper Bretagne – Singles

Brandon Nakashima was the defending champion but chose not to participate.

Vasek Pospisil won the title after defeating Grégoire Barrère 6–4, 3–6, 6–1 in the final.

Seeds
• # Henri Laaksonen (first round)

• # 🇫🇷 Pierre-Hugues Herbert (first round)

• # 🇦🇹 Dennis Novak (semifinals)

• # 🇫🇷 Gilles Simon (first round)

• # 🇨🇦 Vasek Pospisil (champion)

• # João Sousa (quarterfinals)

• # 🇨🇿 Jiří Lehečka (first round)

• # 🇷🇺 Roman Safiullin (first round)