2021 President's Cup II – Singles

Max Purcell was the defending champion but chose not to defend his title.

Andrey Kuznetsov won the title after Jason Kubler retired trailing 3–6, 1–2 in the final.

Seeds
• # 🇷🇺 Roman Safiullin (withdrew)

• # 🇺🇦 Sergiy Stakhovsky (second round)

• # 🇬🇧 Jay Clarke (first round)

• # 🇫🇷 Hugo Grenier (quarterfinals)

• # 🇨🇦 Peter Polansky (quarterfinals)

• # Jesper de Jong (second round)

• # Tseng Chun-hsin (second round)

• # Wu Tung-lin (first round)