2022 President's Cup – Men's singles

Andrey Kuznetsov was the defending champion but chose not to defend his title.

Roman Safiullin won the title after defeating Denis Yevseyev 2–6, 6–4, 7–6(7–2) in the final.

Seeds
• # Roman Safiullin (champion)

• # 🇬🇧 Jay Clarke (first round, retired)

• # 🇰🇿 Dmitry Popko (semifinals)

• # 🇰🇿 Mikhail Kukushkin (second round)

• # 🇰🇿 Timofey Skatov (first round)

• # Evgeny Karlovskiy (second round)

• # Evgeny Donskoy (quarterfinals)

• # 🇺🇦 Illya Marchenko (first round)