2021 Saint-Tropez Open – Singles

This was the first edition of the tournament.

Benjamin Bonzi won the title after Christopher O'Connell retired before the start of the third set in the final with the score at 6–7(10–12), 6–1.

Seeds
• # 🇫🇷 Benjamin Bonzi (champion)

• # 🇦🇺 Christopher O'Connell (final, retired)

• # 🇫🇷 Grégoire Barrère (quarterfinals)

• # 🇮🇳 Prajnesh Gunneswaran (first round)

• # 🇷🇺 Roman Safiullin (first round)

• # 🇸🇪 Elias Ymer (first round)

• # 🇹🇷 Altuğ Çelikbilek (first round)

• # 🇦🇺 Thanasi Kokkinakis (semifinals)